Antibiotic A-23187

Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).(1) It uncouples oxidative phosphorylation.(2) In addition, antibiotic A-23187 inhibits ATPase activity.(3)