Ionomycin
Calcium ionophore / Highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+ influx.2 It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase2. Down regulates beta-catenin/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site.3 In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK/JNK and HSF/HSE interaction leading to upregulation of HSP70 biosynthesis.4
Biochemicals & reagents
56092-81-0
1) Kaufmann et al., (1980) Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria; J. Biol. Chem. 255 2735 2) Elzi et al., (2001) Inonmycin causes actiivation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils; Am. J. Physiol. Cell Physiol. 281 C350 3) Partk et al., (2005) Ionomycin downregulates beta-catenin/tcf signaling in colon cancer cell line; Carcinogenesis, 26 1929 4) Sreedhar and Srinivas (2002) Activation of stress response by ionomycin in rat hepatoma cells; J. Cell Biochem., 86 154
-20°C
TARGET: Ionophore -- PATHWAY: Calcium signaling; JNK pathway; Apoptosis inducer; Autophagy; NAD, NADP pathways -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Infectious disease