Puromycin 2HCl
Translation inhibitor / Puromycin is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3
Biochemicals & reagents
58-58-2
1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes Proc.Nat.Acad.Sci.USA 70 3866 / 2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation EMBO J. 26 1385 / 3) Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction Biochim.Biophys.Acta 1150 89
-20°C
TARGET: Ribosome; Protease; Antibiotic -- PATHWAY: Protein synthesis; Mitochondrial function; Apoptosis inducer -- RESEARCH AREA: Cell death; Neuroscience -- DISEASE AREA: Infectious disease