Antibiotic A-23187
Ca2+ ionophore / Antibiotic A-23187 highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative phosphorylation.2 In addition, A23187 inhibits ATPase activity.3
Biochemicals & reagents
52665-69-7
Calcimycin
1) Reed and Lardy (1972) A23187: a divalent cation ionophore, J. Biol. Chem. 247, 6970 / 2) Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria, Arch. Biochem. Biophys. 156 578 / 3) Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase, J.Biol.Chem. 261 16584
-20°C
TARGET: Ionophore; Substrate / Probe -- PATHWAY: Calcium signaling; Mitochondrial function; Autophagy -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease