Anisomycin
Anoikis sensitizer / Activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Induces apoptosis and sensitizes cells to anoikis. Cell permeable.
Biochemicals & reagents
22862-76-6
1) Hazzalin et al. (1998), Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction; Mol. Cell. Bio., 8 1844. / 2) Mawji et al. (2007), A Chemical Screen Indentifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis; Cancer Res., 67 8307
-20°C
TARGET: Kinase; Ribosome; Antibiotic -- PATHWAY: Protein synthesis; Apoptosis inducer; Anoikis; JNK pathway; Autophagy -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease