Chromomycin A3
DNA Stain / A DNA-binding agent specific for GC-rich sequences1 which may be used as a DNA stain2. Inhibits neuronal apoptosis induced by oxidative stress and DNA damage.3 Inhibits NFB signaling.4 Used in a reliable method for evaluating sperm DNA integrity.5
Biochemicals & reagents
7059-24-7
Aburamycin B; CMA3; NSC-58514
1) Van Dyke et al. (1983), Chromomycin, Mithramycin and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with methidiumpropyl-EDTA)iron(II); Biochemistry, 22 2373 2) Crissman and Tobey (1990), Specific staining of DNA with the fluorescent antibiotic, mithramycin, chromomycin, and olivomycin; Methods Cell Biol., 33 97 3) Chatterjee et al. (2001), Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons; Ann. Neurol., 49 345 4) Miller et al. (2010), Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action; Biochem. Phamracol., 79 1272 5) Dutta et al. (2020), Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmanetation; Andrologia, July 6 e13718 (Online ahead of print)
-20°C
TARGET: DNA; Antibiotic -- PATHWAY: NFkappaB; Transcription; DNA damage; Apoptosis inhibitor -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer