Griseofulvin
Centrosomal clustering inhibitor / Antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus1. Inhibits the growth of adrenocortical cancer cells in vitro2. Inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content3.
Biochemicals & reagents
126-07-8
1) Mauro et al. (2013), The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism; Apoptosis, 18 480 2) Bramann et al. (2013), Griseofulvin inhibits the growth of adrenocortical cancer cells in vitro; Horm. Metab. Res., 45 297 3) Rebacz et al. (2007), Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen; Cancer Res., 67 6342
RT
TARGET: Cytoskeleton; Antibiotic -- PATHWAY: Cell cycle; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease