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Ansamitocin P3

Supplier:
Catalogue number:
10-2199-02
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Microtubule depolymerizer / Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin1,2. Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity against various human tumor cell lines2,3. Maytansine and its analogs cause extensive disassembly of microtubules and totally prevent tubulin spiralization4.

Product Type:

Biochemicals & reagents

CAS Number:

66584-72-3

Reference:

1) Li et al (1992) Binding selectivity of rhizoxin, phomopsin A, vinblastine and ansamitocin P-3 to fungal tubulins: differential interactions of thes antimitotic agents with brain and fungal tubulins; Biochem. Biophys. Res. Commun., 187 722 2) Venghateri et al. (2013) Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding at the Vinblastine Site; PLoS ONE 8 e75182 3) Suwanborirux et al. (1990) Ansamitocin P-3, a maytansinoid, from claopodium crispifolium and anomodo attenuates or associated actinomycetes; Experientia 46 117 4) Ootsu et al. (1980) Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro; Cancer Res. 40 1707

Storage Temperature:

-20°C

Additional Information:

TARGET: Cytoskeleton; Antibiotic -- PATHWAY: Cytotoxicity -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; Infectious disease