Piericidin A
Mitochondrial complex I inhibitor / A potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I).1 Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme.2 It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology.3-5 Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).6
Biochemicals & reagents
2738-64-9
Piericidin A1; Shaoguanmycin B; SN 198E; AR-054
1) Fato et al. (2009), Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species; Biochim. Biophys. Acta, 1787 384 2) Zhou and Fenical (2016), The unique chemistry and biology of the piericidins; J. Antibiot. (Tokyo)., 69 582 3) Bongard et al. (2015), The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q1 (CoQ1); Free Radic. Biol. Med., 79 69 4) Lee et al. (2013), Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes; Free Radic. Biol. Med., 65 584 5) Choi et al. (2011), Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a parkinson's disease model; J. Cell Biol., 192 873 6) Hwang et al. (2008), Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down regulator; J. Cell Physiol., 215 243
-20°C
TARGET: Energy production; Antibiotic -- PATHWAY: Mitochondrial function; NAD, NADP pathways -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease