Bleomycin Sulfate
Induces double strand DNA breaks / Coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage3. Commonly used to induce lung fibrosis in animal disease models4,5. Anticancer agent in clinical use6.
Biochemicals & reagents
9041-93-4
1) Petering et al. (1990), The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact., 73 133 2) Huttenhofer et al. (1992), Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem., 267 24471 3) Lee et al. (2017), ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks; Mol. Cell 68 61 4) Xie et al. (2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res., 17 103 5) Inomata et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res., 15 16 6) Tanaka et al. (2008) Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res., 28 2663
-20°C
TARGET: DNA; Antibiotic -- PATHWAY: DNA damage; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Inflammation; CancerInfectious disease