Genistein
Tyrosine kinase inhibitor / A naturally occurring flavonoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase.1,2 Phytoestrogen3 and agonist at GPR304. Displays cancer chemopreventive activity.5
Biochemicals & reagents
446-72-0
4’,5,7-Trihydroxyisoflavone
1) Akiyama et al. (1987), Genistein, a specific inhibitor of tyrosine-specific protein kinases; J. Biol. Chem., 262 5592 2) Linassier et al. (1990), Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor if EGF receptor tyrosine kinase Biochem. Pharmacol., 39 187 3) Dang et al. (2003), Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein; J. Biol. Chem.,278 962 4) Vivacqua et al. (2006), 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30; Mol. Phamracol., 70 1414 5) Sarker and Li (2002), Mechanisms of cancer chemoprevention by soy isoflavone genistein; Cancer Metastasis Rev., 21 265
-20°C
TARGET: GPCR; Kinase; Antibiotic -- PATHWAY: Estrogen; Cell cycle; AMPK pathway -- RESEARCH AREA: Angiogenesis -- DISEASE AREA: Cancer; Infectious diseaseDiabetes