Epirubicin HCl
DNA damaging agent / Antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with DNA unwinding, strand separation and helicase activity3. Induces myocardial disfunction as a side effect to chemotherapy4.
Biochemicals & reagents
56390-09-1
1) Cersosimo et al. (1986), Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue; J. Clin. Oncol., 4 425 2) Spadari et al. (1986), DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs; Anticancer Res., 6 935 3) Minotti et al. (2004), Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity; Pharmacol. Rev., 56 185 4) Mercuro et al. (2007), Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers; Oncologist, 12 1124
-20°C
TARGET: Topoisomerase; DNA; Antibiotic -- PATHWAY: DNA damage; Transcription; DNA synthesis -- DISEASE AREA: Cancer; Infectious disease