Oligomycin complex
Mitochondrial ATPase inhibitor / Inhibits mitochondrial F1F0 ATP synthase1. A useful tool for decreasing cellular ATP levels2. Induces autophagy3. Stimulates lysosome acidification4. Protects against ischemic kidney in male rats5.
Biochemicals & reagents
1404-19-9
1) Antoniel et al. (2014), The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology; J. Mol. Sci., 15 7513 2) Ng et al. (2014), Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity; Mol. Cell Biol., 34 1427 3) Tettamonti et al. (2006), Oligomycin A induces autophagy in the IPLB-LdFB insect cell line; Cell Tissue Res., 326 179 4) van Dyke et al. (1993), Acidifcation of rat liver lysosomes:quantification and comparison with endosomes; Am. J. Physiol., 265 C901 5) Tanaka et al. (2013), Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats; J. Pharmacol. Sci., 123 227
-20°C
TARGET: ATP synthase; Lysosome; Antibiotic -- PATHWAY: Autophagy; Mitochondrial function; Intracellular transport; Apoptosis inhibitor -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Kidney disease; IschemiaInfectious disease