Camptothecin
Topoisomerase I inhibitor / Camptothecin is a natural product isolated from the chinese Happy tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. It binds irreversibly to the topoisomerase I /DNA complex preventing DNA re-ligation and generating permanent double strand breaks. Potent antitumor agent.
Biochemicals & reagents
7689-03-4
1) Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol. Chem. 260 14873 / 2) Li et al. (2006) Review camptothecin: current perspectives Curr.Med.Chem. 13 2021
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TARGET: Topoisomerase; DNA; Antibiotic -- PATHWAY: DNA synthesis; Transcription; Apoptosis inducer -- RESEARCH AREA: Cell death; Cellular stress -- DISEASE AREA: Cancer; Infectious diseaseObesity