FK-506
Supplier:
Catalogue number:
10-1103-02
Size:
50 mg
Product is available in:
FKBP inhibitor. mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.
- Datasheet: view or download
- Applications:Approved drug (U.S.) that could be repurposed
Product Type:
Biochemicals & reagents
CAS Number:
104987-11-3
Range:
1) Yu et al. (2006), Effects of cyclosporine A, FK506 and rapamycin on clacineurin phosphatase activity in mouse brain; IUBMB Life, 58 429
Limit of Detection:
804.04
Storage Temperature:
-20°C
Additional Information:
FK-506 induces immunosuppression by inhibiting T cell proliferation. It aso inhibits FKBP12 and calcineurin (IC50 ~ 1 nM) and is cell permeable.