Ebselen
Glutathione peroxidase mimic / Novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent1. Displays protective effects in reperfusion injury and stroke2. Excellent scavenger of peroxynitrite3. Acts as a glutathione peroxidase mimetic4. Cell permeable.
Biochemicals & reagents
60940-34-3
PZ-51
1) Schewe et al. (1995), Molecular actions of ebselen – an anti-inflammatory antioxidant; Gen. Pharmacol., 26 1153 / 2) Parnham et al. (2000), Ebselen: prospective therapy for cerebral ischaemia; Expert. Opin. Investig. Drugs, 9 607 / 3) Masumoto et al. (1996), Kinetic study of the reaction of ebselen with peroxynitite; FEBS Lett., 398 179 / 4) Nakamura et al. (2002), Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis; J. Biol. Chem., 277 2687
RT
TARGET: Glutathione; Antioxidant; Protease -- PATHWAY: Redox; Apoptosis inhibitor -- RESEARCH AREA: Cell death; Neuroscience; Oxidative stress -- DISEASE AREA: Inflammation; Infectious diseaseMood disorders; Ischemia