Daunorubicin HCl
DNA damaging agent - Anticancer agent / Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells.4 Cell permeable.
Biochemicals & reagents
23541-50-6
Daunomycin; Rubidomycin; RP-13057
1) Laurent and Jaffrezou (2001), Signaling pathways activated by daunorubicin; Blood 98 913 2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016 3) Masquelier et al. (2004), Relationship between daunorubicin concentration and apoptosis induction in leukemic cells; Biochem.Pharmacol. 67 1047 4) Han et al. (2011), Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells; PLoS One 6 e28491
-20°C
TARGET: Topoisomerase; DNA; Antibiotic -- PATHWAY: DNA damage; Autophagy; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; Infectious disease