Ascomycin
FKBP ligand; immunosuppressant / Analog of FK-506. Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Displays antiinflammatory effects in skin diseases3. Cell permeable and active in vivo.
Biochemicals & reagents
11011-38-4
FK-520; FR-900520
1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosupressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729
-20°C
TARGET: PPIase; Phosphatase; Molecular glue -- PATHWAY: mTOR; Transcription -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation; Infectious disease