Cycloheximide-N-ethylethanoate
FKBP12 inhibitor / FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog, BpML1 (Burkholderia pseudomallei Mip-like protein 1).2
Biochemicals & reagents
Unknown
1) Christner et al. (1999), Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors if FKBP12 with neuroregenerative properties; J. Med. Chem., 42 3615 2) Norville et al. (2011), The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development; Biochem. J., 437 413
-20°C
TARGET: PPIase -- RESEARCH AREA: Immunology; Neuroscience -- DISEASE AREA: Neurodegeneration