MG-132

MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate) and also inhibits calpain (IC50=1.25 μM).(1) Suppresses gastric cancer cell proliferation and induces macro-autophagy (2). Activates stress kinases and induces Hsp72.(3) Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).(4) Cell permeable.