SR9243
LXR inverse agonist / SR9243 is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types including SW620 (IC50 = 40 nM), HT-29 (IC50 = 104 nM), DU-145 (IC50 = 15 nM), PC-3 (IC50 = 61 nM), NCI-H23 (IC50 = 72 nM), HOP-62 (IC50 = 26 nM) and MIAPACA-2 (IC50 = 18 nM). SR9243 is able to promote apoptotic cancer cell death without adversely affecting non-malignant cells.
Biochemicals & reagents
1613028-81-1
1) Flaveny et al. (2015), Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell, 28 42
-20°C
TARGET: Transcription factor -- PATHWAY: Apoptosis inducer; Cholesterol metabolism; Fatty acid metabolism; Warburg effect; Transcription -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; Obesity