Formononetin
PPARg activator; increases adipocyte thermogenesis / A naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPAR activity.1 Activates AMP-activated protein kinase/-catenin signaling to inhibit adipogenesis.2 Accelerates wound repair by increasing expression of Egr-1 transcription factor.3 Potential cancer chemopreventive and chemotherapeutic.4 Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5
Biochemicals & reagents
485-72-3
7-Hydroxy-4'-methoxyisoflavone; Biochanin B; Neochanin; NSC 93360; Formononetol
1) Nie et al. (2018), The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR? activity; Br. J. Pharmacol., 175 1439 2) Gautam et al. (2017), Formononetin, an isoflavone, activates AMO-activated protein kinase/ß-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit., 117 645 3) Huh et al. (2011), Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol., 11 46 4) Ong et al. (2019), Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel), 11 E611 5) Li et al. (2018), Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother., 106 349
-20°C
TARGET: Transcription factor -- PATHWAY: AMPK pathway; PPAR; Transcription -- RESEARCH AREA: Neuroscience; Wound healing; Diabetes; Angiogenesis -- DISEASE AREA: Cancer; NeurodegenerationDiabetes; Obesity