ICG-001
Wnt/β-catenin inhibitor / Inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction
Biochemicals & reagents
847591-62-2
1) Emami et al. (2004), A small molecule inhibitor of β-catenin/CREB-binding protein transcription; Proc. Natl. Acad. Sci. USA, 101 12682 2) Zhou et al. (2012), Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP); J. Biol. Chem., 287 7026
-20°C
TARGET: Transcription factor -- PATHWAY: Wnt; Transcription; Mitochondrial function -- RESEARCH AREA: Cell death; Stem cells; Cellular stress; Neuroscience -- DISEASE AREA: Cancer; Neurodegeneration