C-176
Supplier:
Catalogue number:
10-4130-02
Size:
50 mg
Product is available in:
STING antagonist / C-176 is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.
Product Type:
Biochemicals & reagents
CAS Number:
314054-00-7
Reference:
1) Haag et al. (2018), Targeting STING with covalent small-molecule Inhibitors; Nature 559 269
Storage Temperature:
-20°C
Additional Information:
TARGET: STING -- PATHWAY: Cytokine; Posttranslational modification -- RESEARCH AREA: Immunology; Neuroscience -- DISEASE AREA: Inflammation; Infectious disease