H-151
Supplier:
Catalogue number:
10-4132-01
Size:
10 mg
Product is available in:
STING antagonist / H-151 is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
Product Type:
Biochemicals & reagents
CAS Number:
941987-60-6
Reference:
1) Haag et al. (2018), Targeting STING with covalent small-molecule Inhibitors; Nature 559 269
Storage Temperature:
-20°C
Additional Information:
TARGET: STING -- PATHWAY: Cytokine; Posttranslational modification -- RESEARCH AREA: Immunology; Neuroscience -- DISEASE AREA: Inflammation; Infectious disease