HPA (Hexyl-4-pentynoic acid)
HDAC inhibitor / Histone deacetylase (HDAC) inhibitor, IC50=13 µM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 µM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons2. Cell permeable.
Biochemicals & reagents
96017-59-3
HPA
1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272 / 2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127
RT
TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics