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EX-527

Supplier:
Catalogue number:
10-1083-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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SIRT1 inhibitor / Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

49843-98-3

Reference:

1) J.M. Solomon, et al. (2006), Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage; Mol. Cell Biol.; 26 :28 / 2) J.L. Anderson et al. (2011) Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage; Mol. Celll 43:834

Storage Temperature:

-20°C

Additional Information:

TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification; p53 -- RESEARCH AREA: Epigenetics; Stem cells; Neuroscience -- DISEASE AREA: Neurodegeneration; Ageing