EX-527
SIRT1 inhibitor / Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.
Biochemicals & reagents
49843-98-3
1) J.M. Solomon, et al. (2006), Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage; Mol. Cell Biol.; 26 :28 / 2) J.L. Anderson et al. (2011) Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage; Mol. Celll 43:834
-20°C
TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification; p53 -- RESEARCH AREA: Epigenetics; Stem cells; Neuroscience -- DISEASE AREA: Neurodegeneration; Ageing