www.mayflowerbio.com
Sales & Support: 314-485-5210

*

TM-2-51

Supplier:
Catalogue number:
10-1522-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
$190.00 Shipping is calculated in checkout

HDAC8 activator / Highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. Rescues the activity of catalytically compromised HDAC8 mutants in vitro.2

Product Type:

Biochemicals & reagents

CAS Number:

4921-82-8

Reference:

1) Singh et al. (2011), Histone deacetylase activators: N-acetylthioureas as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate; Bioorg.Med.Chem.Lett., 21 5920 2) Decross et al. (2014), Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders; ACS Chem.Biol. 9 2157 3) Singh et al. (2015), Mechanism of N-acylthiourea Mediated Activation of Human Histone Deacetylase 8 (HDAC*) at Molecular and Cellular Levels; J.Biol.Chem 290 6607

Storage Temperature:

-20°C

Additional Information:

TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics