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HPA (Hexyl-4-pentynoic acid)

Supplier:
Catalogue number:
10-1160-02
Size:
100 mg
Product is available in:
  • USA
  • Canada
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HDAC inhibitor / Histone deacetylase (HDAC) inhibitor, IC50=13 µM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 µM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons2. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

96017-59-3

Alternative Names:

HPA

Reference:

1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272 / 2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127

Storage Temperature:

RT

Additional Information:

TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics