Sirtinol
SIRT inhibitor / Inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60μM), human SIRT2 (IC50=58μM), and yeast Sir2 (IC50=48μM) with no inhibition of human HDAC1. Active in vivo and in purified enzyme studies. Cell permeable.
Biochemicals & reagents
410536-97-9
1) Ota et al.; (2006) SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells Oncogene 25 176 / 2) Mai et al. (2005) Design, synthesis and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors J. Med. Chem. 48 7789 / 3) Grozinger et al. (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening J. Biol. Chem. 276 38837 / 4) Koering et al. (2002) Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity EMBO Rep. 3 1055
-20°C (protect from light)
TARGET: Protein deacetylase -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics; Stem cells; Neuroscience -- DISEASE AREA: Neurodegeneration; Inflammation