Echinomycin
HIF1α inhibitor / Echinomycin is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice against relapsed acute myeloid leukemia with no effect on hematopoietic stem cells.2 Selectively eliminates cancer stem cells in mouse lymphoma and human AML xenogeneic models.3 A very useful tool for probing genes regulated by HIF1α.4
Biochemicals & reagents
512-64-1
Quinomycin A; NSC-13502
1) Kong et al. (2005), Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity; Cancer Res., 65 9047 2) Wang et al. (2014), Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells; Blood, 124 1127 3) Wang et al. (2011), Targeting HIF1α eliminates cancer stem cells in hematological malignancies; Cell Stem Cell., 8 399 4) Li et al. (2015), Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia; Cell Stress Chaperones, 20 507
-20°C
TARGET: Transcription factor; Antibiotic -- PATHWAY: Redox; Transcription -- RESEARCH AREA: Cancer Stem Cells; Oxidative stress -- DISEASE AREA: Cancer; Infectious disease