Caerulomycin A
Blocks STAT1 signaling / Immunosuppressant / A chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFNγ secretion in vitro and in vivo1. Induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling2.
Biochemicals & reagents
21802-37-9
1) Singla et al. (2014), Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One, 9(10) e107051 2) Gurram et al. (2014), Caerulomycin A enhances transforming growth factor-beta (TGF-beta)-Smad3 protein signaling by suppressing interferon-gamma (IFN-gamma)-signaling to expand regulatory T cells (Tregs) J. Biol. Chem. 289 17515
-20°C
TARGET: Transcription factor; Antibiotic -- PATHWAY: Cytokine; JAK/STAT; Transcription; TGF-beta -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation; Infectious disease