Zidovudine
Antiretroviral / Enhances CRISPR repair / Zidovudine was the first clinically useful antiretroviral medicine.1,2 Newer antiretroviral medications have replaced it in the clinic. It selectively inhibits reverse transcriptase acting via the triphosphate metabolite. Zidovudine has recently been found to enhance CRISPR-mediated homology-directed repair (HDR) efficiency.3
Biochemicals & reagents
30516-87-1
Azidothymidine; AZT
1) Yarchoan et al. (1989), Clinical Pharmacology of 3-Azido-2’,3’-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides; N.Engl.J.Med. 321 726 2) D’Andrea et al. (2008), AZT: an old drug with new perspectives; Curr.Clin.Pharmacol. 3 20 3) Yu et al. (2015), Small molecules enhance CRISPR genome editing in pluripotent stem cells; Cell Stem Cell. 16 142
-20°C
TARGET: Reverse transcriptase inhibitor; Antibiotic -- RESEARCH AREA: CRISPR -- DISEASE AREA: Infectious disease