Ansatrienin B
Cytotoxic activity / Represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4
Biochemicals & reagents
82189-04-6
Mycotrienin II; Antibiotic T2311
1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. antibiot. (Tokyo), 35 1467 2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949 3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361
-20°C
TARGET: Ribosome; Antibiotic -- PATHWAY: Protein synthesis; Cytotoxicity -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; InflammationInfectious disease