Metergoline
Serotonin 5HT1,2,7 antagonist / Ergot alkaloid derivative acting as antagonist at serotonin 5HT1 and 5HT2 receptors1,2 and 5HT7 receptors3. A safe and effective agent for management of hyperprolactinemic amenorrhea and anovulation.4 Displays a long-lasting antidepressant effect in seasonal affective disorder.5
Biochemicals & reagents
17692-51-2
Aulakh et al. (1992), Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats; J. Pharmacol. Exp. Ther., 263 588 Bagdy et al. (1992), Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists; Eur. J. Pharmacol., 210 285 Knight et al. (2009), Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists; Mol. Pharmacol., 75 374 Falsetti et al. (1982), Metergoline in the management of hyperprolactinemia amenorrhea and anovulation; Gynecol. Obstet. Invest., 13 108 Turner et al. (2002), Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder; J. Clin. Psychopharmacol., 22 216
-20°C
TARGET: Monoamine receptor; Serotonin; Ion channel -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Mood disorders