Monensin Na
Golgi transport inhibitor / Monovalent-selective ionophore antibiotic, typically employed as a Na+ ionophore.1 Interferes with vesicular transport through the Golgi aparatus2 and induces Golgi swelling3. Neutralizes intracellular compartments such as the trans Golgi apparatus cisternae, lysosomes, and certain endosomes4 (inducing EGFR endosomal arrest for example5). Induces the cleavage of full-length CREB3 in HEK293 cells.6
Biochemicals & reagents
22373-78-0
NSC-343257
Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767
RT
TARGET: Ionophore; Glycosylation; Lysosome -- PATHWAY: Intracellular transport; Apoptosis inducer -- RESEARCH AREA: Vesicles; Cell death -- DISEASE AREA: Infectious disease