Benztropine mesylate
Induces remyelination of neurons / Centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3 Inhibits hepatitis C virus infection.4
Biochemicals & reagents
132-17-2
1) Zhang et al. (2001), Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues; J. Med. Chem., 44 3937 2) Schmitt et al. (2008), Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist binding properties; J. Neurochem., 107 928 3) Deshmukh et al. (2013), A regenerative approach to the treatment of multiple sclerosis; Nature, 502 327 4) Mingorance et al. (2014), Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine: Agents Chemother., 58 3451
RT
TARGET: Monoamine transporter; Dopamine; GPCR -- PATHWAY: ACh (Acetylcholine) signaling -- RESEARCH AREA: Immunology; Neuroscience -- DISEASE AREA: Inflammation; Infectious disease