Hypericin
Protein kinase C inhibitor / Natural product found in St. John’s Wort (Hypericum perforatum). A multifunctional agent that has been reported to be antidepressive, antineoplastic, antitumor and antiviral. Inhibitory effects have been demonstrated on various enzyme including MAO, PKC, dopamine-ß-hydroxylase, reverse transcriptase, telomerase and CYP.1 Hypericin can cause photosensitivity – as a result, it is being investigated as an agent in photodynamic therapy.2
Biochemicals & reagents
548-04-9
1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm.Des. 11 233 / 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol.Pharmacol 6 1775
-20°C
TARGET: Monoamine oxidase; Serotonin; Kinase -- PATHWAY: DNA damage; Apoptosis inducer -- RESEARCH AREA: Neuroscience; Cell death -- DISEASE AREA: Mood disorders; Infectious disease