Cordycepin
AMPK activator / An adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammatory effects1,3 and neuroprotective effects by inhibiting A-induced apoptosis in hippocampal neurons4. Induces apoptosis in a variety of cancer cell lines5. Displays antiobesity effects.6 Inhibits cell senescence via activation of AMPK.7 Maintains stem cell pluripotency and increases iPS cell generation efficiency.8
Biochemicals & reagents
73-03-0
NSC 63984
1) Kim et al. (2011), Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP; Mol.Med. 17 893 2) Kondrashov et al. (2012), Inhibition of polyadenylation reduces inflammatory gene induction; RNA 18 2236 3) Yang et al. (2017), Cordycepin inhibits LPS-induced inflammatory response by modulating NOD-Like Receptor Protein 3 inflammasome activation; Biomed.Pharmacother. 95 1777 4) Song et al. (2018), Neuroprotective efects of cordycepin inhibit A?-induced apoptosis in hippocampal neurons; Neurotoxicology 68 73 5) Zhang et al. (2018), Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo; OncoTargets Ther. 11 4479 6) Li et al. (2018), Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor; Curr.Pharm.Des. Aug.20 epub 7) Wang et al (2019) Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and SMPK in rodents; Nat. Commun. 10 2538 8) Wang et al. (2020) The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency; Sci. Rep. 10 2187
-20°C
TARGET: RNA; PARP; Inflammasome -- PATHWAY: Protein synthesis; Senescence -- RESEARCH AREA: Neuroscience; Stem cells -- DISEASE AREA: Cancer; ObesityDiabetes; Inflammation; Neurodegeneration