Mithramycin A
Transcription inhibitor / Inhibits DNA methyl transferase1. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibitings their expression2. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis3.
Biochemicals & reagents
18378-89-7
A2371; Antibiotic LA 7017; Aureolic Acid; NSC 24559; PA 144; Plicamycin
1) Lin et al. (2007), Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells; Anticancer Drugs, 18 1157 2) Jia et al. (2010), Combined treatment of pancreatic cancer cells with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic anti-tumor activity; Cancer Res., 70 1111 3) Lee et al. (2006), Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites; Mol. Cancer Ther., 5 2737
-20°C
TARGET: DNA methylation; RNA; Antibiotic -- PATHWAY: Transcription; Apoptosis inducer; Chromatin -- RESEARCH AREA: Epigenetics; Cell death -- DISEASE AREA: Infectious disease