Tunicamycin
ER stress inducer / Fermentation product from Streptomyces lysosuperificus. Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs varying in the number of carbon atoms in the fatty acid chain. The structure shown above is for tunicamycin B (the C15 homolog) Potent inhibitor of GlcNAc phosphotransferase which thereby inhibits glycoprotein biosynthesis1. Causes endoplasmic reticulum stress-induced autophagy2 and unfolded protein response3. Arrests cell cycle in late G14.
Biochemicals & reagents
11089-65-9
1) Langan et al. (1991), Isoprenoids and astroglial cell cycling: diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms; J. Cell Physiol., 149 284 2) Ding et al. (2007), Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival; J. Biol. Chem., 282 4702 3) Jiang et al. (2007), Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response; Cancer Res., 67 5880 4) Ishii et al. (1987), Dolichol-linked glycoprotein synthesis in G1 is necessary for DNA synthesis in synchronized primary cultures of cerebral glia; J. Neurochem., 49 1606
-20°C
TARGET: ER/Golgi; UPR (Unfolded Protein Response); Antibiotic -- PATHWAY: Autophagy; Cell cycle; GlcNAc; Degradation; NFkappaB -- RESEARCH AREA: Cellular stress; Ubiquitin/Proteasome; Cell death -- DISEASE AREA: Infectious disease