www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Gliotoxin

Supplier:
Catalogue number:
10-2076-01
Size:
1 mg
Product is available in:
  • USA
  • Canada
$85.00 Shipping is calculated in checkout

Immunomodulator / A fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B cells.1 Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. It inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells.5

Product Type:

Biochemicals & reagents

CAS Number:

67-99-2

Alternative Names:

Aspergillin

Reference:

1) Waring & Beaver (1996), Gliotoxin and related epipolythiodioxopiperazines; Gen. Pharmacol., 27 1311 2) Kroll et al. (1999), The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome; Chem. Biol., 6 689 3) Fitzpatrick et al. (2000), In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats; Dig. Dis. Sci., 45 2327 4) Konig et al. (2019), Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene As4 Hydrolase ; Cell Chem. Biol., 26 524 5) Hubmann et al. (2020), Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL; Cells, 9 1484

Storage Temperature:

-20°C

Additional Information:

TARGET: Nox (NADH/NADPH oxidase); Protease; Antibiotic -- PATHWAY: NFkappaB; Cytokine; NAD, NADP pathways; Lipid signaling -- RESEARCH AREA: Immunology; Oxidative stress -- DISEASE AREA: Inflammation; Infectious diseaseCancer