Dexamethasone
Apoptosis inducing glucocorticoid / A synthetic anti-inflammatory glucocorticoid. Induces apoptosis in a variety of cell types1,2. It inhibits proliferation of A549 human lung adenocarcinoma cells and induces cell surface expression of lipocortin-13. Induces osteogenic differentiation of human mesenchymal stem cells4. Induces indoleamine-2,3-dioxygenase (IDO) and exerts IDO-dependent protection in a model of allergic airway inflammation5. Resets and synchronizes circadian clock in cultured cells6.
Biochemicals & reagents
50-02-2
1. HO Fernhead et al. Biochem. Pharmacol. 1994 48:1073 2. D Chauhan et al. J. Biol. Chem. 2000 275:27845 3. JD Croxtall and RJ Flower Proc. Natl. Acad. Sci. USA 1992 89:3571 4. YC Liu et al. Biosci. Trends 2014 8:138 5. U Grohmann et al. Nat. Med. 2007 13:579 6. Y Zhuang et al. Cell 2023 186:3245
RT
TARGET: Transcription factor; Glycosylation -- PATHWAY: Apoptosis inducer; Autophagy; Transcription -- RESEARCH AREA: Cell death; Immunology; Stem cells; Circadian clock -- DISEASE AREA: Inflammation