Leflunomide
Immunosuppressant / A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury3.
Biochemicals & reagents
75706-12-6
RS-34821
1) Teschner et al. (2010), Leflunomide: a drug with a potential beyond rheumatology; Immunotherapy, 2 637 2) Davis et al. (1996), The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270 3) Latchoumycandane et al. (2007), Mitochondrial protection by the JNK ninhibitor leflunomide rescues mice from acetaminophen-induced liver injury; Hepatology, 45 412
RT
TARGET: Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH) -- PATHWAY: Nucleoside/tide biosynthesis; TNF; Cytokine; Transcription; DNA synthesis -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation; Infectious disease