Thalidomide
E3 UB ligase inhibitor / Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic.
Biochemicals & reagents
50-35-1
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345 / 2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195 / 3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082
RT
TARGET: Ubiquitin ligase; Molecular glue -- PATHWAY: Degradation; Posttranslational modification -- RESEARCH AREA: Ubiquitin/Proteasome; Immunology -- DISEASE AREA: Cancer