FTY720 HCl
Sphingosine-1-phosphate receptor agonist / An analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3)1. Potently inhibits regulatory T cell proliferation in vitro and in vivo2. Enhances microvascular remodeling via expansion of arterioles and capillary networks3. Potent immunomodulator4.
Biochemicals & reagents
162359-56-0
Fingolimod
1) Brinkmann et al. (2002), The immune modulator FTY720 targets spingosine-1-phosphate receptors; J. Biol. Chem., 277 21453 2) Wolf et al. (2009), The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo; J. Immunol., 183 3751 3) Awojoodu et al. (2013), Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis; Proc. Natl. Acad. Sci. USA, 110 13785 4) Chiba (2005), FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors; Pharmacol. Ther., 108 308
-20°C
TARGET: GPCR -- PATHWAY: Sphingolipid metabolism; Proliferation -- RESEARCH AREA: Immunology; Neuroscience; Angiogenesis -- DISEASE AREA: Diabetes