Etoposide
Supplier:
Catalogue number:
10-1123-02
Size:
500 mg
Product is available in:
Topoisomerase II inhibitor / Chemotherapeutic agent. Etoposide forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Blocks the cell cycle in S-phase and G2-phase.
Product Type:
Biochemicals & reagents
CAS Number:
33419-42-0
Alternative Names:
VP-16
Reference:
1) Hande (1998) Etoposide: four decades of development of a topoisomerase II inhibitor:; Eur. J. Cancer 34, 1514 / 2) Smith et.al. (1994) Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells. Br J Cancer. 70 914
Storage Temperature:
RT
Additional Information:
TARGET: Topoisomerase; DNA -- PATHWAY: DNA damage; Transcription; Cell cycle; Apoptosis inducer; Autophagy -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer