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Etoposide

Supplier:
Catalogue number:
10-1123-01
Size:
100 mg
Product is available in:
  • USA
  • Canada
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Topoisomerase II inhibitor / Chemotherapeutic agent. Etoposide forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Blocks the cell cycle in S-phase and G2-phase.

Product Type:

Biochemicals & reagents

CAS Number:

33419-42-0

Alternative Names:

VP-16

Reference:

1) Hande (1998) Etoposide: four decades of development of a topoisomerase II inhibitor:; Eur. J. Cancer 34, 1514 / 2) Smith et.al. (1994) Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells. Br J Cancer. 70 914

Storage Temperature:

RT

Additional Information:

TARGET: Topoisomerase; DNA -- PATHWAY: DNA damage; Transcription; Cell cycle; Apoptosis inducer; Autophagy -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer