www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Doxorubicin HCl

Supplier:
Catalogue number:
10-2130-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
$105.00 Shipping is calculated in checkout

DNA damaging agent / Antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Induces apoptosis in a variety of cell lines2. Substrate for MDR13. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

25316-40-9

Alternative Names:

Adriamycin; NSC-123127

Reference:

1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561 2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565 3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813

Storage Temperature:

-20°C

Additional Information:

TARGET: DNA; Antibiotic -- PATHWAY: Apoptosis inducer; Autophagy; DNA damage; Senescence -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease; Cancer