Doxorubicin HCl
DNA damaging agent / Antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Induces apoptosis in a variety of cell lines2. Substrate for MDR13. Cell permeable.
Biochemicals & reagents
25316-40-9
Adriamycin; NSC-123127
1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561 2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565 3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813
-20°C
TARGET: DNA; Antibiotic -- PATHWAY: Apoptosis inducer; Autophagy; DNA damage; Senescence -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease; Cancer