Forskolin
Adenylate cyclase activator / Forskolin is a widely used adenylate cyclase activator.1 It also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5
Biochemicals & reagents
66575-29-9
Coleonol
1) Awad et al (1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258 2960 / 2) Bhat et al (1983) The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity. J.Med.Chem. 26 486 / 3) de Souza, et al.; (1983) Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties Med. Res. Rev. 3 201 / 4) Aylwin & White (1992) Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors Mol. Pharmacol. 41 908 / 5) Insel & Ostrom (2003) Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling Cell Mol. Neurobiol. 23 305
RT
TARGET: Adenylyl cyclase; GPCR -- PATHWAY: Coagulation; Apoptosis inhibitor; Autophagy; cAMP / cGMP signaling -- RESEARCH AREA: Stem Cells; Cell death -- DISEASE AREA: Hypertension